Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways

In cystic fibrosis (CF), airway mucus becomes thick and viscous, and its clearance from the airways is impaired. The gel-forming mucins undergo an ordered “unpacking/maturation” process after granular release that requires an optimum postsecretory environment, including hydration and pH. We hypothes...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:JCI Insight
Huvudupphovsmän: Abdullah, Lubna H., Evans, Jessica R., Wang, T. Tiffany, Ford, Amina A., Makhov, Alexander M., Nguyen, Kristine, Coakley, Raymond D., Griffith, Jack D., Davis, C. William, Ballard, Stephen T., Kesimer, Mehmet
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358479/
https://ncbi.nlm.nih.gov/pubmed/28352653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89752
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk