Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways

In cystic fibrosis (CF), airway mucus becomes thick and viscous, and its clearance from the airways is impaired. The gel-forming mucins undergo an ordered “unpacking/maturation” process after granular release that requires an optimum postsecretory environment, including hydration and pH. We hypothes...

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Vydáno v:JCI Insight
Hlavní autoři: Abdullah, Lubna H., Evans, Jessica R., Wang, T. Tiffany, Ford, Amina A., Makhov, Alexander M., Nguyen, Kristine, Coakley, Raymond D., Griffith, Jack D., Davis, C. William, Ballard, Stephen T., Kesimer, Mehmet
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358479/
https://ncbi.nlm.nih.gov/pubmed/28352653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89752
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