Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways

In cystic fibrosis (CF), airway mucus becomes thick and viscous, and its clearance from the airways is impaired. The gel-forming mucins undergo an ordered “unpacking/maturation” process after granular release that requires an optimum postsecretory environment, including hydration and pH. We hypothes...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Abdullah, Lubna H., Evans, Jessica R., Wang, T. Tiffany, Ford, Amina A., Makhov, Alexander M., Nguyen, Kristine, Coakley, Raymond D., Griffith, Jack D., Davis, C. William, Ballard, Stephen T., Kesimer, Mehmet
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358479/
https://ncbi.nlm.nih.gov/pubmed/28352653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89752
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