Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow depends on the relative mucin concentration of the mucus layer compared with that of the periciliary layer; however, mucin...

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Detalhes bibliográficos
Main Authors: Henderson, Ashley G., Ehre, Camille, Button, Brian, Abdullah, Lubna H., Cai, Li-Heng, Leigh, Margaret W., DeMaria, Genevieve C., Matsui, Hiro, Donaldson, Scott H., Davis, C. William, Sheehan, John K., Boucher, Richard C., Kesimer, Mehmet
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072023/
https://ncbi.nlm.nih.gov/pubmed/24892808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73469
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