Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate immune antiviral response that prevents propagation of virus infection by selectively inhibiting translation of viral mRNA. It relies on its ability to compete with the translation initiation factor eIF4F...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Abbas, Yazan M., Laudenbach, Beatrice Theres, Martínez-Montero, Saúl, Cencic, Regina, Habjan, Matthias, Pichlmair, Andreas, Damha, Masad J., Pelletier, Jerry, Nagar, Bhushan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358387/
https://ncbi.nlm.nih.gov/pubmed/28251928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612444114
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