Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations

IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate immune antiviral response that prevents propagation of virus infection by selectively inhibiting translation of viral mRNA. It relies on its ability to compete with the translation initiation factor eIF4F...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Abbas, Yazan M., Laudenbach, Beatrice Theres, Martínez-Montero, Saúl, Cencic, Regina, Habjan, Matthias, Pichlmair, Andreas, Damha, Masad J., Pelletier, Jerry, Nagar, Bhushan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358387/
https://ncbi.nlm.nih.gov/pubmed/28251928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612444114
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