Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons

The eukaryotic 43S preinitiation complex (PIC) bearing Met-tRNA(i)(Met) in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA leader for an AUG codon in favorable “Kozak” context. AUG recognition provokes rearrangement from an open PIC conformation with TC bound in a...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Dong, Jinsheng, Aitken, Colin Echeverría, Thakur, Anil, Shin, Byung-Sik, Lorsch, Jon R., Hinnebusch, Alan G.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358355/
https://ncbi.nlm.nih.gov/pubmed/28223523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620569114
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