BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naïve CD4(+) T cells to produce mature...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Cheung, Kalung, Lu, Geming, Sharma, Rajal, Vincek, Adam, Zhang, Ruihua, Plotnikov, Alexander N., Zhang, Fan, Zhang, Qiang, Ju, Ying, Hu, Yuan, Zhao, Li, Han, Xinye, Meslamani, Jamel, Xu, Feihong, Jaganathan, Anbalagan, Shen, Tong, Zhu, Hongfa, Rusinova, Elena, Zeng, Lei, Zhou, Jiachi, Yang, Jianjun, Peng, Liang, Ohlmeyer, Michael, Walsh, Martin J., Zhang, David Y., Xiong, Huabao, Zhou, Ming-Ming
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358349/
https://ncbi.nlm.nih.gov/pubmed/28265070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615601114
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