BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naïve CD4(+) T cells to produce mature...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Cheung, Kalung, Lu, Geming, Sharma, Rajal, Vincek, Adam, Zhang, Ruihua, Plotnikov, Alexander N., Zhang, Fan, Zhang, Qiang, Ju, Ying, Hu, Yuan, Zhao, Li, Han, Xinye, Meslamani, Jamel, Xu, Feihong, Jaganathan, Anbalagan, Shen, Tong, Zhu, Hongfa, Rusinova, Elena, Zeng, Lei, Zhou, Jiachi, Yang, Jianjun, Peng, Liang, Ohlmeyer, Michael, Walsh, Martin J., Zhang, David Y., Xiong, Huabao, Zhou, Ming-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358349/
https://ncbi.nlm.nih.gov/pubmed/28265070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615601114
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