Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains

BRD4, characterized by two acetyl-lysine binding bromodomains and an extra-terminal (ET) domain, is a key chromatin organizer that directs gene activation in chromatin through transcription factor recruitment, enhancer assembly, and pause release of the RNA polymerase II complex for transcription el...

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Autori principali: Zhang, Guangtao, Plotnikov, Alexander N., Rusinova, Elena, Shen, Tong, Morohashi, Keita, Joshua, Jennifer, Zeng, Lei, Mujtaba, Shiraz, Ohlmeyer, Michael, Zhou, Ming-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3894848/
https://ncbi.nlm.nih.gov/pubmed/24144283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401334s
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