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Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains
BRD4, characterized by two acetyl-lysine binding bromodomains and an extra-terminal (ET) domain, is a key chromatin organizer that directs gene activation in chromatin through transcription factor recruitment, enhancer assembly, and pause release of the RNA polymerase II complex for transcription el...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3894848/ https://ncbi.nlm.nih.gov/pubmed/24144283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401334s |
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