Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains

[Image: see text] A protein structure-guided drug design approach was employed to develop small molecule inhibitors of the BET family of bromodomains that were distinct from the known (+)-JQ1 scaffold class. These efforts led to the identification of a series of substituted benzopiperazines with str...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Millan, David S., Kayser-Bricker, Katherine J., Martin, Matthew W., Talbot, Adam C., Schiller, Shawn E. R., Herbertz, Torsten, Williams, Grace L., Luke, George P., Hubbs, Stephen, Alvarez Morales, Monica A., Cardillo, Daniel, Troccolo, Paul, Mendes, Rachel L., McKinnon, Crystal
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554895/
https://ncbi.nlm.nih.gov/pubmed/28835800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00191
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