An MLH1 Mutation Links BACH1/FANCJ to Colon Cancer, Signaling, and Insight toward Directed Therapy

Defects in MLH1, as with other mismatch repair (MMR) proteins, are the primary cause of hereditary nonpolyposis colon cancer (HNPCC). Mutations in MMR genes often disrupt mismatch repair and MMR signaling functions. However, some HNPCC-associated mutations have unknown pathogenicity. Here, we uncove...

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Bibliografiske detaljer
Udgivet i:Cancer Prev Res (Phila)
Main Authors: Xie, Jenny, Guillemette, Shawna, Peng, Min, Gilbert, Candace, Buermeyer, Andrew, Cantor, Sharon B.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358091/
https://ncbi.nlm.nih.gov/pubmed/20978114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0118
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