Depression of oncogenecity by dephosphorylating and degrading BCR-ABL

Aberrant phosphorylation and overexpression of BCR-ABL fusion protein are responsible for the main pathogenesis in chronic myeloid leukemia (CML). Phosphorylated BCR-ABL Y177 recruits GRB2 adaptor and triggers leukemic RAS-MAPK and PI3K-AKT signals. In this study, we engineered a SPOA system to deph...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Gao, Miao, Huang, Zheng-Lan, Tao, Kun, Xiao, Qing, Wang, Xin, Cao, Wei-Xi, Xu, Min, Hu, Jing, Feng, Wen-Li
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356883/
https://ncbi.nlm.nih.gov/pubmed/27926512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13754
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