Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus

The chimeric Bcr-Abl oncoprotein, which causes chronic myeloid leukemia, mainly localizes in the cytoplasm, and loses its ability to transform cells after moving into the nucleus. Here we report a new strategy to convert Bcr-Abl to be an apoptotic inducer by altering its subcellular localization. We...

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Hlavní autoři: Huang, Zheng-Lan, Gao, Miao, Li, Qian-Yin, Tao, Kun, Xiao, Qing, Cao, Wei-Xi, Feng, Wen-Li
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3926824/
https://ncbi.nlm.nih.gov/pubmed/24158537
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