Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases

BACKGROUND: The bcr-abl fusion gene is the pathological origin of chronic myeloid leukemia (CML) and plays a critical role in the resistance of imatinib. Thus, bcr-abl disruption-based novel therapeutic strategy may warrant exploration. In our study, we were surprised to find that the characteristic...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Huang, Ningshu, Huang, Zhenglan, Gao, Miao, Luo, Zhenhong, Zhou, Fangzhu, Liu, Lin, Xiao, Qing, Wang, Xin, Feng, Wenli
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859405/
https://ncbi.nlm.nih.gov/pubmed/29554925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0732-4
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