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Controlling Subcellular Localization to Alter Function: Sending Oncogenic Bcr-Abl to the Nucleus Causes Apoptosis
Altering the subcellular localization of signal transducing proteins is a novel approach for therapeutic intervention. Mislocalization of tumor suppressors, oncogenes, or factors involved in apoptosis result in aberrant functioning of these proteins, leading to disease. In the case of chronic myelog...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787801/ https://ncbi.nlm.nih.gov/pubmed/19576252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.06.026 |
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