IMPROVED COILED-COIL DESIGN ENHANCES INTERACTION WITH BCR-ABL AND INDUCES APOPTOSIS

The oncoprotein Bcr-Abl drives aberrant downstream activity through trans-autophosphorylation of homo-oligomers in chronic myelogenous leukemia (CML).(1,2) The formation of Bcr-Abl oligomers is achieved through the coiled-coil domain at the N-terminus of Bcr.(3, 4) We have previously reported a modi...

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Hauptverfasser: Dixon, Andrew S., Miller, Geoffrey D., Bruno, Benjamin J., Constance, Jonathan E., Woessner, David W., Fidler, Trevor P., Robertson, James C., Cheatham, Thomas E., Lim, Carol S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313827/
https://ncbi.nlm.nih.gov/pubmed/22136227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200461s
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