Heterozygous mutation of cysteine(528) in XPO1 is sufficient for resistance to selective inhibitors of nuclear export

Exportin-1 (CRM1/XPO1) is a crucial nuclear export protein that transports a wide variety of proteins from the nucleus to the cytoplasm. These cargo proteins include tumor suppressors and growth-regulatory factors and as such XPO1 is considered a potential anti-cancer target. From this perspective,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Neggers, Jasper Edgar, Vanstreels, Els, Baloglu, Erkan, Shacham, Sharon, Landesman, Yosef, Daelemans, Dirk
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356594/
https://ncbi.nlm.nih.gov/pubmed/27634897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11995
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