Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs

mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Pan, Yongchu, Liu, Hongliang, Wang, Yanru, Kang, Xiaozheng, Liu, Zhensheng, Owzar, Kouros, Han, Younghun, Su, Li, Wei, Yongyue, Hung, Rayjean J., Brhane, Yonathan, McLaughlin, John, Brennan, Paul, Bickeböller, Heike, Rosenberger, Albert, Houlston, Richard S., Caporaso, Neil, Teresa Landi, Maria, Heinrich, Joachim, Risch, Angela, Wu, Xifeng, Ye, Yuanqing, Christiani, David C., Amos, Christopher I., Wei, Qingyi
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356340/
https://ncbi.nlm.nih.gov/pubmed/28304396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44634
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