Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) is an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PF...

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Publicado en:Sci Rep
Autores principales: Komiya, Chikara, Tanaka, Miyako, Tsuchiya, Kyoichiro, Shimazu, Noriko, Mori, Kentaro, Furuke, Shunsaku, Miyachi, Yasutaka, Shiba, Kumiko, Yamaguchi, Shinobu, Ikeda, Kenji, Ochi, Kozue, Nakabayashi, Kazuhiko, Hata, Ken-ichiro, Itoh, Michiko, Suganami, Takayoshi, Ogawa, Yoshihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355985/
https://ncbi.nlm.nih.gov/pubmed/28303974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44754
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