Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) is an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PF...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Komiya, Chikara, Tanaka, Miyako, Tsuchiya, Kyoichiro, Shimazu, Noriko, Mori, Kentaro, Furuke, Shunsaku, Miyachi, Yasutaka, Shiba, Kumiko, Yamaguchi, Shinobu, Ikeda, Kenji, Ochi, Kozue, Nakabayashi, Kazuhiko, Hata, Ken-ichiro, Itoh, Michiko, Suganami, Takayoshi, Ogawa, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355985/
https://ncbi.nlm.nih.gov/pubmed/28303974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44754
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