Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH

Sodium glucose cotransporter 2 (SGLT2) inhibitors, an antidiabetic drug, promotes urinary excretion of glucose by blocking its reabsorption in the renal proximal tubules. It is unclear whether SGLT2 inhibition could attenuate nonalcoholic steatohepatitis (NASH) and NASH-associated hepatocellular car...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shiba, Kumiko, Tsuchiya, Kyoichiro, Komiya, Chikara, Miyachi, Yasutaka, Mori, Kentaro, Shimazu, Noriko, Yamaguchi, Shinobu, Ogasawara, Naomi, Katoh, Makoto, Itoh, Michiko, Suganami, Takayoshi, Ogawa, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799179/
https://ncbi.nlm.nih.gov/pubmed/29402900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19658-7
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