Antifibrotic effect of pirfenidone in a mouse model of human nonalcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH) is characterized by steatosis with lobular inflammation and hepatocyte injury. Pirfenidone (PFD) is an orally bioavailable pyridone derivative that has been clinically used for the treatment of idiopathic pulmonary fibrosis. However, it remains unknown whether PF...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Komiya, Chikara, Tanaka, Miyako, Tsuchiya, Kyoichiro, Shimazu, Noriko, Mori, Kentaro, Furuke, Shunsaku, Miyachi, Yasutaka, Shiba, Kumiko, Yamaguchi, Shinobu, Ikeda, Kenji, Ochi, Kozue, Nakabayashi, Kazuhiko, Hata, Ken-ichiro, Itoh, Michiko, Suganami, Takayoshi, Ogawa, Yoshihiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355985/
https://ncbi.nlm.nih.gov/pubmed/28303974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44754
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