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Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2

Recent studies have suggested that selective targeting of overexpressed enzymes in cancer cells by small molecules that induce the formation of reactive oxygen species (ROS) could be a viable approach in cancer therapy. One such example is the inactivation of ubiquitin specific protease-2 (USP2)—an...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Gopinath, Pushparathinam, Mahammed, Atif, Ohayon, Shimrit, Gross, Zeev, Brik, Ashraf
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355956/
https://ncbi.nlm.nih.gov/pubmed/28451143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc02758j
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