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Superoxide signaling and cell death in retinal ganglion cell axotomy: Effects of metallocorroles

Injury to retinal ganglion cell (RGC) axons within the optic nerve causes apoptosis of the soma. We previously demonstrated that in vivo axotomy causes elevation of superoxide anion within the RGC soma, and that this occurs 1–2 days before annexin-V positivity, a marker of apoptosis. Pegylated super...

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Detalhes bibliográficos
Main Authors: Catrinescu, Maria-Magdalena, Chan, Wesley, Mahammed, Atif, Gross, Zeev, Levin, Leonard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479435/
https://ncbi.nlm.nih.gov/pubmed/22366296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2012.02.006
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