Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent

Activating mutations in full length anaplastic lymphoma kinase (ALK) have been reported in neuroblastoma and in anaplastic thyroid cancer. ALK-L1198F and ALK-G1201E mutations were originally identified in anaplastic thyroid cancer (ATC) and characterized as constitutively activating mutations. In th...

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Pubblicato in:Oncotarget
Autori principali: Guan, Jikui, Wolfstetter, Georg, Siaw, Joachim, Chand, Damini, Hugosson, Fredrik, Palmer, Ruth H, Hallberg, Bengt
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355286/
https://ncbi.nlm.nih.gov/pubmed/28030793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14141
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