Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

Pilocytic astrocytoma (PA) is the most frequent pediatric brain tumor. Activation of the MAPK pathway is well established as the oncogenic driver of the disease. It is most frequently caused by KIAA1549:BRAF fusions, and leads to oncogene induced senescence (OIS). OIS is thought to be a major reason...

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Publicado en:Oncotarget
Main Authors: Selt, Florian, Hohloch, Juliane, Hielscher, Thomas, Sahm, Felix, Capper, David, Korshunov, Andrey, Usta, Diren, Brabetz, Sebastian, Ridinger, Johannes, Ecker, Jonas, Oehme, Ina, Gronych, Jan, Marquardt, Viktoria, Pauck, David, Bächli, Heidi, Stiles, Charles D, von Deimling, Andreas, Remke, Marc, Schuhmann, Martin U, Pfister, Stefan M, Brummer, Tilman, Jones, David T.W., Witt, Olaf, Milde, Till
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355278/
https://ncbi.nlm.nih.gov/pubmed/28002790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14004
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