Nutrient-induced FNIP degradation by SCF(β-TRCP) regulates FLCN complex localization and promotes renal cancer progression

Folliculin-interacting protein 1 and 2 (FNIP1 and FNIP2) play critical roles in preventing renal malignancy through their association with the tumor suppressor FLCN. Mutations in FLCN are associated with Birt-Hogg-Dubé (BHD) syndrome, a rare disorder with increased risk of renal cancer. Recent studi...

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Udgivet i:Oncotarget
Main Authors: Nagashima, Katsuyuki, Fukushima, Hidefumi, Shimizu, Kouhei, Yamada, Aya, Hidaka, Masumi, Hasumi, Hisashi, Ikebe, Tetsuro, Fukumoto, Satoshi, Okabe, Koji, Inuzuka, Hiroyuki
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354783/
https://ncbi.nlm.nih.gov/pubmed/28039480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14221
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