VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma

Clear cell Renal Cell Carcinoma (ccRCC) formation is connected to functional loss of the von Hippel-Lindau (VHL) gene. Recent data identified its gene product, pVHL, as a multifunctional adaptor protein which interacts with HIFα subunits but also with the tumor suppressor p53. p53 is hardly expresse...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Razafinjatovo, Caroline Fanja, Stiehl, Daniel, Deininger, Eva, Rechsteiner, Markus, Moch, Holger, Schraml, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354652/
https://ncbi.nlm.nih.gov/pubmed/28052007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14372
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