Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice

Clear cell renal cell carcinomas (ccRCC) frequently exhibit inactivation of the VHL tumour suppressor gene and often harbour multiple copy number alterations in genes that regulate cell cycle progression. We show here that modelling these genetic alterations by combined renal epithelium-specific del...

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Publicado no:Nat Med
Main Authors: Harlander, Sabine, Schönenberger, Désirée, Toussaint, Nora C., Prummer, Michael, Catalano, Antonella, Brandt, Laura, Moch, Holger, Wild, Peter J., Frew, Ian J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509015/
https://ncbi.nlm.nih.gov/pubmed/28553932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4343
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