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Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice
Clear cell renal cell carcinomas (ccRCC) frequently exhibit inactivation of the VHL tumour suppressor gene and often harbour multiple copy number alterations in genes that regulate cell cycle progression. We show here that modelling these genetic alterations by combined renal epithelium-specific del...
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| Publicat a: | Nat Med |
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| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509015/ https://ncbi.nlm.nih.gov/pubmed/28553932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4343 |
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