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VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma

Clear cell Renal Cell Carcinoma (ccRCC) formation is connected to functional loss of the von Hippel-Lindau (VHL) gene. Recent data identified its gene product, pVHL, as a multifunctional adaptor protein which interacts with HIFα subunits but also with the tumor suppressor p53. p53 is hardly expresse...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Razafinjatovo, Caroline Fanja, Stiehl, Daniel, Deininger, Eva, Rechsteiner, Markus, Moch, Holger, Schraml, Peter
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354652/
https://ncbi.nlm.nih.gov/pubmed/28052007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14372
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