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Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast
RNA Polymerase II pauses and backtracks during transcription, with many consequences for gene expression and cellular physiology. Here, we show that the energy required to melt double-stranded nucleic acids in the transcription bubble predicts pausing in Saccharomyces cerevisiae far more accurately...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5354634/ https://ncbi.nlm.nih.gov/pubmed/28301878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174066 |
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