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Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast

RNA Polymerase II pauses and backtracks during transcription, with many consequences for gene expression and cellular physiology. Here, we show that the energy required to melt double-stranded nucleic acids in the transcription bubble predicts pausing in Saccharomyces cerevisiae far more accurately...

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Detalhes bibliográficos
Publicado no:PLoS One
Principais autores: Lukačišin, Martin, Landon, Matthieu, Jajoo, Rishi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354634/
https://ncbi.nlm.nih.gov/pubmed/28301878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174066
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