Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

Soluble ligands have commonly been targeted by antibody therapeutics for cancers and other diseases. Although monoclonal antibodies targeting such ligands can block their interactions with their cognate receptors, they can also significantly increase the half-life of their ligands by FcRn-mediated a...

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Опубликовано в: :J Biol Chem
Главные авторы: Kasturirangan, Srinath, Rainey, G. Jonah, Xu, Linda, Wang, Xinwei, Portnoff, Alyse, Chen, Tracy, Fazenbaker, Christine, Zhong, Helen, Bee, Jared, Zeng, Zhutian, Jenne, Craig, Wu, Herren, Gao, Changshou
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2017
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354496/
https://ncbi.nlm.nih.gov/pubmed/28100773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770628
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