Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

Soluble ligands have commonly been targeted by antibody therapeutics for cancers and other diseases. Although monoclonal antibodies targeting such ligands can block their interactions with their cognate receptors, they can also significantly increase the half-life of their ligands by FcRn-mediated a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Kasturirangan, Srinath, Rainey, G. Jonah, Xu, Linda, Wang, Xinwei, Portnoff, Alyse, Chen, Tracy, Fazenbaker, Christine, Zhong, Helen, Bee, Jared, Zeng, Zhutian, Jenne, Craig, Wu, Herren, Gao, Changshou
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2017
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354496/
https://ncbi.nlm.nih.gov/pubmed/28100773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770628
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