Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

Soluble ligands have commonly been targeted by antibody therapeutics for cancers and other diseases. Although monoclonal antibodies targeting such ligands can block their interactions with their cognate receptors, they can also significantly increase the half-life of their ligands by FcRn-mediated a...

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Uloženo v:
Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Kasturirangan, Srinath, Rainey, G. Jonah, Xu, Linda, Wang, Xinwei, Portnoff, Alyse, Chen, Tracy, Fazenbaker, Christine, Zhong, Helen, Bee, Jared, Zeng, Zhutian, Jenne, Craig, Wu, Herren, Gao, Changshou
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354496/
https://ncbi.nlm.nih.gov/pubmed/28100773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770628
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