CAR T-cell intrinsic PD-1 checkpoint blockade: A two-in-one approach for solid tumor immunotherapy

PD-L1/2 expression in solid tumors inhibits chimeric antigen receptor (CAR) T-cell efficacy. A PD-1 dominant negative receptor expressed in CAR T cells provides cell-intrinsic checkpoint blockade and augments antitumor efficacy. A combinatorial immunotherapeutic strategy of combining CAR T cells wit...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Chen, Nan, Morello, Aurore, Tano, Zachary, Adusumilli, Prasad S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5353939/
https://ncbi.nlm.nih.gov/pubmed/28344886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1273302
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