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Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3862687/ https://ncbi.nlm.nih.gov/pubmed/24353912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26286 |
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