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Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors

Checkpoint blockade (CPB) therapy can elicit durable clinical responses by reactivating an exhausted immune response. However, response rates remain limited, likely secondary to a lack of a tumor-reactive immune infiltrate. Chimeric antigen receptor (CAR) T cells may provide the necessary tumor-targ...

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Detalles Bibliográficos
Publicado en:Cancer Cell
Main Authors: Grosser, Rachel, Cherkassky, Leonid, Chintala, Navin, Adusumilli, Prasad S.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7171534/
https://ncbi.nlm.nih.gov/pubmed/31715131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.09.006
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