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Driving CARs on the uneven road of antigen heterogeneity in solid tumors
Uniform and strong expression of CD19, a cell surface antigen, on cells of B-cell lineage is unique to hematologic malignancies. Tumor-associated antigen (TAA) targets in solid tumors exhibit heterogeneity with regards to intensity and distribution, posing a challenge for chimeric antigen receptor (...
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| Vydáno v: | Curr Opin Immunol |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5943172/ https://ncbi.nlm.nih.gov/pubmed/29554494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2018.03.002 |
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