Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive resistance compromises the efficacy of chimeric antigen receptor (CAR) T cell therapies, which redirect T cells to solid tumors. Here, we investigated whether programmed...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Cherkassky, Leonid, Morello, Aurore, Villena-Vargas, Jonathan, Feng, Yang, Dimitrov, Dimiter S., Jones, David R., Sadelain, Michel, Adusumilli, Prasad S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966328/
https://ncbi.nlm.nih.gov/pubmed/27454297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83092
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