Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade

Death Receptor 5 (DR5) is known to be an important anti-cancer drug target. TRAIL is a natural ligand of DR5, but its drug action is limited because of several factors. A few agonistic ligands were identified as TRAIL-DR5 axis modulators, which enhance the cellular apoptosis. Literature suggest that...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Das, Sarita, Tripathi, Neha, Preet, Ranjan, Siddharth, Sumit, Nayak, Anmada, Bharatam, Prasad V., Kundu, Chanakya Nath
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352116/
https://ncbi.nlm.nih.gov/pubmed/27542249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11335
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