Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors

[Image: see text] A study of structure-based modulation of known ligands of hTopoIIα, an important enzyme involved in DNA processes, coupled with synthesis and in vitro assays led to the establishment of a strategy of rational switch in mode of inhibition of the enzyme’s catalytic cycle. 6-Arylated...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Baviskar, Ashish T., Amrutkar, Suyog M., Trivedi, Neha, Chaudhary, Vikas, Nayak, Anmada, Guchhait, Sankar K., Banerjee, Uttam C., Bharatam, Prasad V., Kundu, Chanakya N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416441/
https://ncbi.nlm.nih.gov/pubmed/25941559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00040
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