Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics

Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In contrast, TOP2 catalytic inhibitors induce limite...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Oncol
Auteurs principaux: Matias-Barrios, Victor M., Radaeva, Mariia, Song, Yi, Alperstein, Zaccary, Lee, Ahn R., Schmitt, Veronika, Lee, Joseph, Ban, Fuqiang, Xie, Ning, Qi, Jianfei, Lallous, Nada, Gleave, Martin E., Cherkasov, Artem, Dong, Xuesen
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Oncology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7883873/
https://ncbi.nlm.nih.gov/pubmed/33598437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.633142
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