Quinacrine induces apoptosis in cancer cells by forming a functional bridge between TRAIL-DR5 complex and modulating the mitochondrial intrinsic cascade

Death Receptor 5 (DR5) is known to be an important anti-cancer drug target. TRAIL is a natural ligand of DR5, but its drug action is limited because of several factors. A few agonistic ligands were identified as TRAIL-DR5 axis modulators, which enhance the cellular apoptosis. Literature suggest that...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Das, Sarita, Tripathi, Neha, Preet, Ranjan, Siddharth, Sumit, Nayak, Anmada, Bharatam, Prasad V., Kundu, Chanakya Nath
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352116/
https://ncbi.nlm.nih.gov/pubmed/27542249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11335
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