5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway

Colorectal cancer (CRC) patients with APC mutations do not benefit from 5-FU therapy. It was reported that APC physically interacts with POLβ and FEN1, thus blocking LP-BER via APC’s DNA repair inhibitory (DRI) domain in vitro. The aim of this study was to elucidate how APC status affects BER and th...

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Dettagli Bibliografici
Pubblicato in:DNA Repair (Amst)
Autori principali: Das, Dipon, Preet, Ranjan, Mohapatra, Purusottam, Satapathy, Shakti Ranjan, Siddharth, Sumit, Tamir, Tigist, Jain, Vaibhav, Bharatam, Prasad V., Wyatt, Michael D., Kundu, Chanakya Nath
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4830146/
https://ncbi.nlm.nih.gov/pubmed/25460919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.10.006
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