Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

Protein misfolding caused by inherited mutations leads to loss of protein function and potentially toxic ‘gain of function’, such as the dominant P23H rhodopsin mutation that causes retinitis pigmentosa (RP). Here, we tested whether the AMPK activator metformin could affect the P23H rhodopsin synthe...

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Библиографические подробности
Опубликовано в: :Hum Mol Genet
Главные авторы: Athanasiou, Dimitra, Aguila, Monica, Opefi, Chikwado A., South, Kieron, Bellingham, James, Bevilacqua, Dalila, Munro, Peter M., Kanuga, Naheed, Mackenzie, Francesca E., Dubis, Adam M., Georgiadis, Anastasios, Graca, Anna B., Pearson, Rachael A., Ali, Robin R., Sakami, Sanae, Palczewski, Krzysztof, Sherman, Michael Y., Reeves, Philip J., Cheetham, Michael E.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351934/
https://ncbi.nlm.nih.gov/pubmed/28065882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw387
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