Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein

The CRISPR/Cas9 system has rapidly advanced targeted genome editing technologies. However, its efficiency in targeting with constructs in mouse zygotes via homology directed repair (HDR) remains low. Here, we systematically explored optimal parameters for targeting constructs in mouse zygotes via HD...

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Enregistré dans:
Détails bibliographiques
Publié dans:Transgenic Res
Auteurs principaux: Jung, Chris J., Zhang, Junli, Trenchard, Elizabeth, Lloyd, Kent C., West, David B., Rosen, Barry, de Jong, Pieter J.
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2016
Sujets:
Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350237/
https://ncbi.nlm.nih.gov/pubmed/27905063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-016-9998-5
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