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Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein
The CRISPR/Cas9 system has rapidly advanced targeted genome editing technologies. However, its efficiency in targeting with constructs in mouse zygotes via homology directed repair (HDR) remains low. Here, we systematically explored optimal parameters for targeting constructs in mouse zygotes via HD...
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| Publicado no: | Transgenic Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5350237/ https://ncbi.nlm.nih.gov/pubmed/27905063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-016-9998-5 |
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