Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein

The CRISPR/Cas9 system has rapidly advanced targeted genome editing technologies. However, its efficiency in targeting with constructs in mouse zygotes via homology directed repair (HDR) remains low. Here, we systematically explored optimal parameters for targeting constructs in mouse zygotes via HD...

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Bibliographic Details
Published in:Transgenic Res
Main Authors: Jung, Chris J., Zhang, Junli, Trenchard, Elizabeth, Lloyd, Kent C., West, David B., Rosen, Barry, de Jong, Pieter J.
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2016
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350237/
https://ncbi.nlm.nih.gov/pubmed/27905063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-016-9998-5
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