Orai and TRPC channel characterization in FcεRI‐mediated calcium signaling and mediator secretion in human mast cells

Inappropriate activation of mast cells via the Fcε RI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed mediators and for synthesis of eicosanoids, cytoki...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Wajdner, Hannah E., Farrington, Jasmine, Barnard, Claire, Peachell, Peter T., Schnackenberg, Christine G., Marino, Joseph P., Xu, Xiaoping, Affleck, Karen, Begg, Malcolm, Seward, Elizabeth P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350174/
https://ncbi.nlm.nih.gov/pubmed/28292887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13166
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